Paloma H. Giangrande, PhD

University of Iowa, Junior Investigator


What is your current professional status?

Associate Professor

What is your work setting?

Academic Institution

What is your scientific area of research?

RNA therapeutics and cell-targeted therapies for cancer and cardiovascular disease

Why do you want to be a mentor?

I view mentoring as the most gratifying activity I perform on a daily basis.

As a mentor, what are you hoping to gain from this experience?

  Hoping to gain as mentor: To inspire mentees to identify their passion for research and pursue a career in scientific research.

How important are the following in the selection of a mentee: (1 – 5 scale, 1 = most important, 5 = least important)

a. Compatibility of Scientific Specialties - 1
b. Geographic Location - 5
c. Professional Status / Success - 3
d. Compatibility of Career Path - 2
e. Communication Style - 3

Provide a biography that describes who you are and what you do in the field of gene and/or cell therapy.

Dr. Giangrande obtained her PhD in 1999 at Duke University in Pharmacology and Cancer Biology. In 2000, she joined the laboratory of Dr. Joseph Nevins where she worked on elucidating the differential roles of the E2F cell cycle regulators. After a four year postdoc, she joined the laboratory of Dr. Bruce Sullenger where she pioneered the use of RNA aptamers for targeted delivery of siRNAs. In 2007 Dr. Giangrande was appointed as Assistant Professor in the Dept. of Internal Medicine at the University of Iowa. Dr. Giangrande's research interests include developing RNA-based therapeutics to modulate cellular pathways underlying pathological cell proliferation in the setting of cancer and cardiovascular disease. A main interest is selecting RNA aptamers to receptors expressed on the surface of target-cells with SELEX (Systematic Evolution of Ligands by EXponential Enrichment) for the purpose of 1) modulating receptor function and/or 2) delivering therapeutic molecules (e.g. siRNAs, antimirs, drugs) into specific cell types.

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2019
22nd Annual Meeting
April 29 – May 2 | Washington D.C.
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