Program  
ASGT 8th Annual Meeting
June 1-5, 2005
 ·  America's Center, St. Louis, MO
Jointly sponsored by Stanford University School of Medicine, Stanford, California
Invitation to Participate | Supporters | Exhibitors | Exhibit Hall Floor Plan | Committee Roster
Abstract Reviewers | General Information | Program-at-a-Glance | Program | Faculty
8th Annual Meeting Home | ASGT Home


Program Schedule

(This program is subject to updates/changes.)

Friday, June 3, 2005

Scientific Symposia
8:00 am - 10:00 am

Scientific Symposium 300
Ethics: Ethical Issues in Clinical Trial Design: Informed Consent and Children

Room: Ferrara Theater
Chair:
R. Scott McIvor, PhD
Speakers:
Adrian J. Thrasher, MD, PhD - Clinical Trials of Gene Therapy for Severe Combined Immunodeficiency
Robert M. Nelson, MD, PhD - Gene Transfer Trials in Children: What’s Ethical? What’s Allowable?
Nancy M.P. King, JD - Children in Gene Transfer Trials: Design, Benefit and Consent Issues
Panel:
Punam Malik, MD
Cynthia Dunbar, MD

Scientific Symposium 301
Gene-Based Vaccines: Cancer Vaccines
Room: 230 Complex
Chair:
Margaret A. Liu, MD
Speakers:
Kristen Hege, MD - GM-CSF Gene-modified Cancer Vaccines
Margaret A. Liu, MD - Clinical Gene-based Cancer Vaccines and Immunotherapy
Malcolm K. Brenner, MD, PhD - Improving the Function and Feasibility of Gene Modified Cancer Vaccines
Dennis Panicali, PhD - Progress in the Development of Poxvirus-based Cancer Vaccines

Scientific Symposium 302
Genetic Diseases: Protein Modifications to Enhance Therapy of Genetic Disease
Room: 240 Complex
Chair:
Valder Arruda, MD, PhD
Speakers:
Jonathan B. Rothbard, PhD - Delivery of Small and Large Molecules into Cells and Tissues with Arginine Rich Transporters
Robert H. Costa, PhD - Use of a Transducing p19ARF Peptide to Induce Apoptosis and Diminish Proliferation of Mouse Hepatocellular Carcinomas
Valder Arruda, MD, PhD - Coagulation Proteins with Improved Biological Properties for Hemostasis Gene Therapy
Nay Wei Soong, PhD - Seven Years in Tibet: Optimizing Therapeutic Proteins by DNA Shuffling
Friday, June 3, 2005

Scientific Symposium 303
Infectious Disease: Gene Therapy for HIV: Lessons Learned, Paradigms to Apply to Other Areas
Room: 260/264
Co-Chairs:
Boro Dropulic, PhD
Ramesh Akkina, DVM, PhD
Speakers:
Dale Ando, MD - Gene Modulation of the HIV Co-receptor CCR5 Using CCR5 Specific Zinc Finger Nucleases
Dorothee Von Laer, MD - Treatment of HIV Infection with Gene Protected Autologous T cells
Carl H. June, MD - Lentiviral Gene Therapy for HIV: A New Paradigm?
John J. Rossi, PhD - RNAi Gene Therapy for HIV-1

Scientific Symposium 304
Musculo-Skeletal: Regenerative Approaches for Skeletal Disorders
Room: 263/267
Chair:
Steven C. Ghivizzani, PhD
Speakers:
Christopher Evans, PhD - Tissue Regeneration Without Manufactured Scaffolds or Cell Culture
Dan Gazit, DMD, PhD - Genetically Engineered Mesenchymal Stem Cells as a Platform for Skeletal Tissue Engineering
Paul D. Robbins, PhD - Gene Therapy for Bone and Cartilage Regeneration
Edward M. Schwarz, PhD - Revitalization of Structural Allografts via Immobilized rAAV Gene Therapy

Break
10:00 am - 10:15 am

Scientific Symposia
10:15 am - 12:15 pm

Scientific Symposium 310
Embryonic Stem Cells and Tissue Engineering

Room: 230 Complex
Chair:
Carolyn Lutzko, PhD
Speakers:
Linda G. Griffith, PhD - Microscale Models of Liver for Analysis of Gene Therapy
Mervin Yoder, MD - Using RNA Interference Approaches to Modulate Gene Expression in ES Cells
Kyunghee Choi, PhD - Stepwise Commitment from Embryonic Stem to Hematopoietic and Endothelial Cells
Michael R. Linden, PhD - AAV-mediated Site-Specific Gene Addition in Embryonic Stem Cells

Scientific Symposium 311
Immunology of Gene Therapy: Immune Response to Gene Transfer Vehicles
Room: 240 Complex
Chair:
Hildegund CJ Ertl, MD
Speakers:
James M. Wilson, MD, PhD - T Cell Responses to Adenoviruses and AAV
Katherine A. High, MD - Immune Responses to Vector and Transgene Product in AAV-mediated Gene Transfer
Thierry C. Vandendriessche, PhD - Transduction of Antigen-Presenting Cells using Viral Vectors: A Double Edged Sword

Scientific Symposium 312
Neural Disorders: Inherited Metabolic Brain Disorders
Room: Ferrara Theater
Chair:
Beverly L. Davidson, PhD
Speakers:
Luigi Naldini, MD, PhD - HSC-based Gene Therapy of Leukodystrophies
John H. Wolfe, VMD, PhD - Gene Therapy for the CNS in Lysosomal Storage Disease
Paola Leone, PhD - Safety and Efficacy of AAV-mediated Gene Transfer for Canavan Disease
Ronald G. Crystal, MD - AAV-mediated Gene Transfer for Batten Disease

Scientific Symposium 313
Nonviral: Nonviral Gene Delivery: Towards Clinical Applications
Room: 260/264
Chair:
Dexi Liu, PhD
Speakers:
Lluis M. Mir, DSc - Electric Pulses-based Gene Transfer: Safety and Efficacy of Combinations of High Voltage and Low Voltage Pulses
Hans J. Lipps, PhD - A Novel Non-viral Episomal Vector as Expression System for Gene Therapy
Michael A. Barry, PhD - Endonucleases as Barriers to Gene Delivery
William M. Pardridge, MD - Intravenous, Non-Viral Gene Therapy of Brain in Rodents and Primates

Scientific Symposium 314
Respiratory Tract: Respiratory Epithelium as a Model for Mucosal Gene Delivery
Room: 263/267
Co-Chairs:
Daniel Weiss, MD, PhD
Patrick L. Sinn, PhD
Speakers:
Stephen Hyde, PhD - Non-viral Vectors for Airway Epithelium: The Pros and Cons
Larry G. Johnson, MD - Cell Biological Considerations in Gene Transfer to Respiratory Epithelia
Jim Hu, PhD - Viral Vectors for Airway Gene Delivery: Pros and Cons
Adriana Heguy, PhD - Microarray Analysis of Gene Expression in the Human Small and Large Airways to Identify Targets for Lung Disease

Meet-the-Investigator Lunch Sessions
12:30 pm - 1:30 pm

Meet- the-Investigator 320
Room: Washington Avenue A
Chair:
Kenneth Cornetta, MD - Integrating Vectors: From Production to Clinic

Meet-the-Investigator 321
Room: Washington Avenue B
Chair:
Cynthia Dunbar, MD - Insertional Mutagenesis and Retroviral Vectors

Meet-the-Investigator 322
Room: Washington Avenue C
Chair:
Adrian J. Thrasher, MD, PhD - Clinical Trials for Immunodeficiency

Meet-the-Investigator 323
Room: Washington Avenue F
Chair:
John Tisdale, MD - Hematopoietic Stem Cell Gene Transfer

Simultaneous Oral Abstract Sessions
2:00 pm – 4:30 pm

Oral Abstract Session 330
RNA Virus Vectors: Integration and Vector Safety

Room: Ferrara Theater
Co-Chairs:
Isabelle Riviere, PhD
Tal Kafri, PhD
(Abstracts #386 - #395)

Oral Abstract Session 331
AAV Vectors: Vector Development
Room: 240 Complex
Co-Chairs:
Saswati Chatterjee, PhD
Guangping Gao, PhD
(Abstracts #396 - #405)

Oral Abstract Session 332
Adenovirus Vectors: Innate Immunity
Room: 120/124
Co-Chairs:
Joseph T. Bruder, PhD
Andrea Amalfitano, DO, PhD
(Abstracts #406 - #415)

Oral Abstract Session 333
Inborn Errors of Metabolism - Liver and Storage Disorders
Room: 260/264
Co-Chairs:
Seng H. Cheng, PhD
Brendan Lee, MD, PhD
(Abstracts #416 - #425)

Oral Abstract Session 334
Neurologic Disorders
Room: 265/266
Chair:
Pedro Lowenstein, MD, PhD
(Abstracts #426 - #435)

Oral Abstract Session 335
Infectious Diseases and Vaccines: RNAi in Gene Therapy for Infections
Room: 230/231
Chair:
Bruce E. Torbett, PhD, MSPH
(Abstracts #436 - #443)

Oral Abstract Session 336
Targeting of Adeno Viral Vectors and Cancer Treatment
Room: 123/127
Co-Chairs:
Estuardo Aguilar-Cordova, PhD
William F. Benedict, MD
(Abstracts #444 - #453)

Oral Abstract Session 337
Advances in Hematologic Gene Therapy
Room: 263/267
Co-Chairs:
Karen E. Pollok, PhD
Christof von Kalle, MD
(Abstracts #454 - #463

Oral Abstract Session 338
Gene Regulation: Regulated Systems and Cell Engineering
Room: 261/262
Co-Chairs:
David Spencer, PhD
James M. Wilson, MD, PhD
(Abstracts #464 - #473)

Poster Session II
4:00 pm - 7:30 pm
Hall 2

RNA Virus Vectors: Gene Transfer, Vector Production
(Abstracts #474 through #496)

AAV Vectors: Vector Biology
(Abstracts #497 through #523)

Adenovirus Vectors: Applications
(Abstracts #524 through #555)

Naked DNA Gene Transfer: Optimizing Expression, Animal Models
(Abstracts #556 through #575)

Lipid Mediated Gene Transfer: Non-Viral Delivery System
(Abstracts # 576 through #596)

Inborn Errors of Metabolism: Hemophilia
(Abstracts #597 through #615)

Cardiovascular: Angiogenesis and Vascular Gene Therapy
(Abstracts #616 through #639; and Abstract #921)

Neurologic: Pain
(Abstracts #640 through #646)

Neurologic: Spinal Cord Injury and Motor Neuron Disease
(Abstracts #647 through #654)

Neurologic: Advances in Vectors, Delivery and Imaging
(Abstracts #655 through #662)

Neurologic: Sensory
(Abstracts #663 through #671)

Gene Therapy for Connective Tissue
(Abstracts #672 through #690)

Cancer - Immunotherapy: Cytokine Transgenes and Vaccinations
(Abstracts #691 through #709)

Cancer - Targeted Gene Therapy: Targeting of Non-Adenoviral Vectors
(Abstracts #710 through #732)

Gene Regulation: Overcoming Obstacles to Gene Transfer and Expression
(Abstracts #733 through #754)

Evening Session
8:30 pm – 10:00 pm

Evening Session 340
Immune Responses in Neurologic Gene Therapy - Basic Bench Perspectives

Target Audience: Anyone interested in immune responses as well as neural gene therapy in the brain.
Room: 261/262
Co-Chairs:
Pedro Lowenstein, MD, PhD
Hildegund CJ Ertl, MD
Speakers:
Ronald G. Crystal, MD
Paola Leone, PhD
James Wilson, MD, PhD
Michael Kaplitt, MD, PhD
John Iacomini, PhD
Roland W. Herzog, PhD
Katherine A. High, MD
Samuel D. Rabkin, PhD
Jean Bennett, MD, PhD
David J. Fink, MD
Ronald Mandel, PhD